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Intermittent Fasting: More Than Just Calories – Hormone Balance and Psychophysiological Resilience

A recent study highlights the profound effects of intermittent fasting on body composition and hormone profiles. Jürg Hösli explains why the psychophysiological response is crucial and how stress management influences success.

7 min read0 ViewsFebruary 25, 2026
Intermittent Fasting: More Than Just Calories – Hormone Balance and Psychophysiological Resilience

Intermittent Fasting: More Than Just Calories – Hormone Balance and Psychophysiological Resilience

Intermittent Fasting (IF) has become a popular approach in recent years for losing weight and improving health. But is it really just a matter of calorie reduction, or are there deeper, psychophysiological mechanisms at play? A recent 24-week study with 120 participants provides exciting insights that go beyond mere body composition and underscore the relevance of Jürg Hösli's holistic approach.

Study Results at a Glance: Calorie Balance vs. Hormone Balance

The study compared three groups: one following the 16:8 fasting model (16 hours fasting, 8-hour eating window), one practicing 5:2 fasting (two days a week with significantly reduced calorie intake), and a control group with conventional calorie restriction. Surprisingly, all three groups showed a similarly significant loss of body fat. This once again confirms that a negative energy balance is a crucial factor for weight loss.

However, the study revealed a crucial difference in hormone profiles: The 16:8 group showed the most favorable results here:

  • Testosterone remained stable: An important marker for muscle mass, libido, and general well-being, especially in men, but also relevant for women.
  • Cortisol was significantly lower than in the calorie restriction group. Cortisol, the primary stress hormone, plays a central role in Jürg Hösli's psychophysiological interaction model.

Jürg Hösli's Perspective: Why Cortisol is Key

These results are of immense importance from Jürg Hösli's perspective. They show that fasting is not just about pure calorie reduction, but about the qualitative response of the body to this intervention.

The significantly lower cortisol level in the 16:8 group is a strong indicator that this form of fasting puts the body less into a state of stress than a continuous, conventional calorie restriction. Persistently elevated cortisol levels, as Jürg Hösli repeatedly emphasizes in his work on the cortisol axis and chronic stress, can have far-reaching negative consequences:

  • Increased stress load: The body perceives constant calorie restriction as a threat, which puts the autonomic nervous system into sympathetic mode (fight-or-flight). This is a transition from load to potential overload.
  • Negative effects on metabolism: Chronically high cortisol levels promote the storage of abdominal fat, disrupt blood sugar balance, and can lead to metabolic bottlenecks.
  • Impairment of regeneration and sleep: Cortisol antagonizes melatonin and can thus reduce sleep quality, which in turn hinders regeneration and disturbs the vegetative balance.
  • Weakening of the immune system: In the long term, cortisol suppresses immune function, increasing susceptibility to diseases.

16:8 fasting seems to provoke a more adaptive stress response here. The body learns to cope with periods of food deprivation without entering a pathological state of overload. This speaks for an improved resilience of the organism, a central goal in Jürg Hösli's work on prevention instead of symptom control.

The Role of the Autonomic Nervous System and HRV

The stabilization of testosterone levels and the reduction of cortisol indicate a positive influence on the sympathetic/parasympathetic balance. A balanced autonomic nervous system is the basis for health, performance, and well-being. Jürg Hösli uses HRV (Heart Rate Variability) as a biomarker to make this vegetative balance measurable. It would be exciting to see how HRV values developed in the different fasting groups, as higher HRV generally correlates with better stress adaptation and lower cortisol.

Practical Relevance: Individualized Nutrition and Performance Optimization

The study underscores Jürg Hösli's credo: Not just 'what', but 'why' and 'for whom' is crucial in nutrition. While intermittent fasting can be beneficial for many, it is not a universal solution. This is where individualized nutrition comes into play.

Important note for athletes: The study indicates that for intensive strength training, nutrient intake should be aligned with the training. A 16:8 fasting window may work well for some in recreational sports, but for competitive athletes who complete high training volumes, a longer fasting window can lead to energy deficits and suboptimal regeneration. Here, a precise adjustment of macro and micronutrient intake to the training plan is essential to prevent muscle breakdown and optimize performance. In his work with world champions and in recreational sports, Jürg Hösli has always emphasized that nutrition is a central pillar of performance optimization that must be tailored to individual needs and intensity of exertion.

Psychological Predispositions and Stress Processing

It is also important to consider that the response to fasting can depend on psychological predispositions. For people who are already under high stress or have a tendency towards perfectionistic behavior, a strict fasting protocol could create additional pressure and thus paradoxically increase cortisol levels instead of lowering them. Here, a mindful approach and, if necessary, support from an experienced coach are crucial to avoid the transition from healthy load to pathological overload.

Conclusion: Connecting Knowledge with Action

The results of this study underpin the necessity of a holistic view of nutrition and health. Intermittent fasting is more than a diet strategy; it is an intervention that can have profound effects on our hormone balance and our stress response. Success depends not only on calorie balance but significantly on the psychophysiological resilience of the individual.

Jürg Hösli's psychophysiological interaction model provides the ideal framework for interpreting such findings and translating them into practical, individualized recommendations for action. It is about recognizing patterns before symptoms arise and bringing the body into an optimal balance through conscious action – for sustainable health and performance.